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BIOMOLECULES AT SURFACES

 

Detailed understanding of the interactions between materials surfaces and biological structures as well as living systems plays a key role for the development of innovative MedTech solutions.

In biomimetic approaches biomolecules can function as optimal natural mediators for highly desired properties that are not directly provided by the materials alone. Such surface properties comprise for example specific attraction of cells to surfaces, biocatalytic activity or antimicrobial effects to prevent biofilm formation. Thus, the unique expertise of the group lies in combining two strategies: materials science with solutions provided by Nature.

Materials surfaces can be decorated with biomolecules of choice following innovative protocols. The group aims to steer surface properties of materials through the use of biomolecules for targeting two fields of application: therapy and diagnosis. Such hybrid materials are analysed and investigations of their performance are carried out.

Apart from enabling processes, such as for example improved cell attachment, an additional aim for the development of therapeutic devices is the investigation of events occurring at materials surfaces when exposed to biological fluids.

Moreover, immobilized biomolecules such as enzymes, engineered probe-proteins and antibodies allow for the specific sensing of biomarkers in complex biological samples. With this we aim for the fabrication of innovative biosensors for healthcare issues.




 

Contact:

Dr. Katharina Maniura
Katharina.Maniura@empa.ch
Tel.: +41 (0)58 765 74 47

Empa
Swiss Federal Laboratories for Materials Science and Technology
Laboratory for Biointerfaces
Lerchenfeldstrasse 5
9014 St. Gallen
Schweiz


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